I have been running my freshwater through a Pandora's box - which really makes it sound cool, just raw through a reverb amp it has that kind of classic Gretsch sound familiar to Neil Young' type of heavy electric sound.
But I think I could be a bit more versatile with a solid body electric, with high gain and sustain ( been watching alot of Jimi Hendrix DVD's), was thinking along the lines of a 10 string with the low C added, but strings still in courses. Not sure where you get a pickup with that kind of string spacing ? I know at one time Ithica Strings was making a solid body electric mandocello -don't think they are still in production.
I think the body and neck would not tbe a big problem but the bridge and pickups might be hard to find.