The lowest note on your mando is at the top of Lester's G-run. If you're chopping off-beats, trying to tie the chords together with runs will just get in the guitarist's way. Not to say you wouldn't want to think of some way to tie chords together in certain circumstances, but probably not the same kind of runs a guitar uses.
Think about emphasizing the "seventh' note just before you change from a I to a IV chord, or sliding your chord up to the new one. There are neat transitions you can try between chords.
Gibsn: '54 F5 3pt F2 A-N Custm K1 m'cello
Natl Triolian Dobro mando
Victoria b-back Merrill alumnm b-back
Stradolin Vega banjolin
Sobell'dola Washburn b-back'dola
Eastmn: 615'dola 805 m'cello
Flatiron 3K OM